Inventions & Discoveries · Medicine and health

Trepanning

c. 6500 BCE · Also known as Trepanation, Trephination

Trepanning, or trepanation, is a surgical intervention in which a hole is drilled or scraped into the human skull, perhaps the oldest surgical procedure with archaeological evidence; at a burial site in France dated to 6500 BCE, 40 of 120 skulls had trepanation holes. More than 1,500 trephined skulls of the Neolithic period have been found in Europe, Siberia, China and the Americas, and many show that the patient survived. Performed with tools of stone, obsidian, bronze or bone, it was described by Hippocrates and Galen and survives in modern craniotomy.

Trepanning
Image: Rama · CC BY-SA 3.0 fr · Wikimedia Commons

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First known
c. 6500 BCE
Where
France

NoteEstimates of the earliest trepanation vary from 10,000 to 7,000 years ago.

Built onStone tools3.3 million years ago

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See also

Cite this entry
APA
The Epoch Institute. (2026). Trepanning. In The Epoch Institute Encyclopedia. https://the-epoch-institute.org/encyclopedia/trepanning
MLA
“Trepanning.” The Epoch Institute Encyclopedia, The Epoch Institute, 2026, https://the-epoch-institute.org/encyclopedia/trepanning. Accessed .
Chicago
The Epoch Institute. “Trepanning.” The Epoch Institute Encyclopedia. 2026. https://the-epoch-institute.org/encyclopedia/trepanning.
Harvard
The Epoch Institute (2026) ‘Trepanning’, The Epoch Institute Encyclopedia. Available at: https://the-epoch-institute.org/encyclopedia/trepanning (Accessed: ).

Last reviewed October 2026Random entry ↻