Glossary · Term

Smallpox

Smallpox is a highly contagious viral disease that was a leading cause of death in many societies until its eradication in 1980. Brought to the Americas by Europeans, it devastated Indigenous populations with no prior immunity. The Aztec Empire and Spanish Empire profiles note that a smallpox epidemic weakened Tenochtitlan during the Spanish conquest.

Mentioned in 9 profiles

Mentioned in 6 state histories

See also

Cite this entry
APA
The Epoch Institute. (2026). Smallpox. In The Epoch Institute Encyclopedia. https://the-epoch-institute.org/encyclopedia/smallpox
MLA
“Smallpox.” The Epoch Institute Encyclopedia, The Epoch Institute, 2026, https://the-epoch-institute.org/encyclopedia/smallpox. Accessed .
Chicago
The Epoch Institute. “Smallpox.” The Epoch Institute Encyclopedia. 2026. https://the-epoch-institute.org/encyclopedia/smallpox.
Harvard
The Epoch Institute (2026) ‘Smallpox’, The Epoch Institute Encyclopedia. Available at: https://the-epoch-institute.org/encyclopedia/smallpox (Accessed: ).

Last reviewed October 2026Random entry ↻